Steven W. Mamus, M.D.

Medical Director, Oncology/Hematology
Steve Mamus, M.D. is a nationally-renowned medical oncologist with more than two decades of expertise in the treatment of cancer and blood related disorders.

In November of 2006, Dr. Mamus founded the Cancer Center of Sarasota in order to bring personal, patient-centered care blended with university-based medical expertise to cancer patients in the Sarasota area. Dr. Mamus was instrumental in the development of MD Anderson Cancer Center — Orlando where he was chief of medical oncology and treated patients acutely affected by cancer for more than 10 years.

His oncology and hematology experience includes positions at Hematology/Oncology Associates of Central Florida from 1986 to 1991; Orlando Cancer Center from 1991 to 1994; and MD Anderson Cancer Center — Orlando from 1994 to 2004. Prior to developing the Cancer Center of Sarasota, he was a principal partner of Cancer Centers of Florida, a division of U.S. Oncology.

Dr. Mamus is recognized regionally and nationally with a long list of awards and accomplishments as an oncology/hematology physician, clinical research expert, and educator. He has been an investigator in more than 100 clinical trials involving a wide range of oncology/hematology modalities including biologic response modifiers, stem cell, bone marrow, and blood clotting abnormalities. He has published a number of articles and publications in peer-reviewed journals including The New England Journal of Medicine, Lancet, The Journal of Clinical Investigation and Leukemia Research.

Among his awards, Dr. Mamus was named a top physician by Best Doctors in America, Southeast Region for 14 consecutive years, and Attending Physician of the Year at Orlando Regional Medical Center. Dr. Mamus graduated with honors from Harvard and earned his M.D. from the State University of New York at Syracuse. He interned and completed his residency in Internal Medicine at Rush-Presbyterian St. Luke’s Hospital in Chicago, and completed his fellowship in Hematology/Oncology at the University of Minnesota Hospital.

Dr. Mamus is board certified in Medical Oncology, Hematology, and Internal Medicine and is a member of the American Medical Association, Florida Medical Association, American Society of Hematology and the American Society of Clinical Oncology.

Dr. Mamus is of Ukrainian descent, was born in Canada, and lives in Sarasota with his wife Nancy, son and three daughters. Two of his daughters were adopted from the Ukraine and he has had a child with acute leukemia.

Education

July 1983 – June 1986
Fellow, Hematology/Oncology, University of Minnesota Hospital, Minneapolis, Minnesota
July 1981 – June 1983
Resident, Internal Medicine, Rush-Presbyterian St. Luke’s Hospital Chicago, Illinois
July 1980 – June 1981
Intern, Internal Medicine, Rush Presbyterian St. Luke’s Hospital Chicago, Illinois
Aug 1976 – June 1980
MD- State University of New York at Syracuse
Aug 1972 – June 1976
BA- Harvard College

Licensure

1986 Florida Licensure

Board Certification

American Board of Internal Medicine – Medical Oncology
American Board of Internal Medicine – Hematology
American Board of Internal Medicine – Internal Medicine

Professional Experience

11/2006 – Present
Medical Director - Cancer Center of Sarasota-Manatee, Sarasota and Bradenton, Florida
2/2004 – 10/2006
Cancer Centers of Florida (US Oncology), Orlando, Florida
7/1991 – 1/2004
M.D. Anderson Cancer Center – Orlando, Orlando, Florida
7/1986- 7/1991
Hematology/Oncology Associates of Central Florida, Orlando, Florida

Chronology of Employment and Appointments

1980-1983 Clinical Instructor, Rush Medical College, Chicago, Illinois
1980-1981 Intern, Internal Medicine, Rush-Presbyterian St. Luke’s Hospital, Chicago, Illinois
1981-1983 Resident, Internal Medicine, Rush-Presbyterian St. Luke’s Hospital, Chicago, Illinois
1983-1986 Fellow, Hematology/Oncology, University of Minnesota Hospital
1986-2006 Active Staff, Orlando Regional Medical Center, Orlando, Florida
1986-2006 Active Staff, ORMC, Sand Lake Campus, Orlando, Florida
1986-1991 Group Practice, Hematology/Oncology Associates of Central Florida, Orlando, Florida
1986-1991 Courtesy Staff, Brookwood Community Hospital, Orlando, Florida
1986-1992 Courtesy Staff, Florida Hospital, Orlando, Florida
1991-1994 Orlando Cancer Center, Orlando, Florida
1994-2004 M.D. Anderson Cancer Center Orlando, Florida
2000-2003 Director, Institutional Review Board, MD Anderson, Orlando
2002 National Speaker’s Bureau, Astra-Zeneca Pharmaceuticals
2002 Advisory Board Southeast Region Astra-Zeneca
2002 Executive Breast Cancer Advisory Council, Novartis Pharmaceuticals
2002-2005 Speaker’s Bureau, Amgen
2002-2004 Advisory Board Lilly Pharmaceuticals
2002 Advisory Board Ortho Biotech
2002-2003 Advisory Board Roche Pharmaceuticals
1995-2005 Chief, Hematology-Medical Oncology, Orlando Regional
2002-2003 Chief, Medical Oncology, MD Anderson-Orlando
2002-2003 Section chief, Melanoma, MD Anderson-Orlando
2002-2003 Section chief, Soft Tissue Sarcoma, MD Anderson-Orlando
2002-2003 Section chief, Breast Carcinoma, MD Anderson-Orlando
2004-2006 Active medical staff Florida Hospital System
2004-2006 Active medical staff Health Central Hospital
2005-2006 Active medical staff Osceola Regional Medical Center
2005-2006 National Pharmaceutical and Therapeutics Committee, US Oncology
2006-present Active Medical Staff- Sarasota Memorial Hospital, Manatee Memorial Hospital, Blake Hospital, Lakewood Ranch Hospital and Doctors’ Hospital
2011-present Clinical Assistant Professor, Florida State University School of Medicine
2012-present Lab Director Max Health, High Complexity Laboratory
2013 Steering Committee, Hospitalist Service, Sarasota Memorial Hospital
2014-present Clinical Associate Professor, Lake Erie College of Osteopathic Medicine (LECOM)
2014-present Chief of Hematology, Blake trauma unit

Hospitals

Active Medical Staff Memberships
Sarasota Memorial Hospital
Doctors Hospital of Sarasota
Manatee Memorial Healthcare System
Blake Medical Center
Lakewood Ranch Medical Center

Societies

1982-Present American Medical Association
1982-1983 American College of Emergency Physicians
1983-1986 American College of Physicians
1984-1986 American Federation for Clinical Research
1986-Present Florida Medical Association
1986-2006 Orange County Medical Society
1986-Present American Society of Hematology
1988-1989 Board of Trustees, Leukemia Society of America, Orlando Chapter
1989-Present American Society of Clinical Oncology
2007-Present Sarasota County Medical Society
2009-Present Manatee County Medical Society
2013-Present American Association of Cancer Research

Awards

1976 BA, cum laude, Harvard College
1984 Third Prize, Officer-Fellow Abstract Award, American Federation for Clinical Research, Midwestern Section
1985 First Prize, Midwest Trainee Award, American Federation for Clinical Research, Midwestern Section
1986 Research grant for study of Interferon Effects on Normal Hematopoiesis
National Institutes of Health, Heart and Lung Institute (unrestricted individual grant for $450,000.00-declined in favor of private practice).
1987 Attending Physician of the Year, Orlando Regional Medical Center, Department of Internal Medicine
1996 The Best Doctors in America, Southeast Region
1997 The Best Doctors in America, Southeast Region
1998 The Best Doctors in America, Southeast Region
1999 The Best Doctors in America, Southeast Region
2000 The Best Doctors in America, Southeast Region
2001 The Best Doctors in America, Southeast Region
2001 American College of Physicians Excellence in Teaching Award
2002 The Best Doctors in America, Southeast Region
2003 The Best Doctors in America, Southeast Region
2004 The Best Doctors in America, Southeast Region
2005 The Best Doctors in America, Southeast Region
2006 The Best Doctors in America, Southeast Region
2007 The Best Doctors in America, Southeast Region
2008 The Best Doctors in America, Southeast Region
2009 The Best Doctors in America, Southeast Region
2010 The Best Doctors in America, Southeast Region
2011 The Best Doctors in America, Southeast Region
2011 Best Doctors, Sarasota Magazine, U.S. News and World Report
2012 People’s Physician Choice Award
2012 The Best Doctors in America, Southeast Region
2012 Best Doctors, Sarasota Magazine, U.S. News and World Report
2013 Best Doctors, Sarasota Magazine, U.S. News and World Report
2013 The Best Doctors in America, Southeast Region
2013 People’s Physician Choice Award
2014 Best Doctors, Sarasota Magazine, U.S. News and World Report
2014 The Best Doctors in America, Southeast Region
2015 Chosen by the International Association of Oncologists as a Top Oncologist in Sarasota, FL and listed in the publication The Leading Physicians of the World
2015 Best Doctors, Sarasota Magazine, U.S. News and World Report
2015 The Best Doctors in America, Southeast Region

Publications

  1. Mamus SW, Mladenovic J, Hordinsky MK, Dahl M and Kay NE. (1984) Cimetidine induced remission of mycosis fungoides. Lancet, II: 409.
  2. Mamus SW, Beck-Schroeder SL and Zanjani ED. (1985) Suppression of normal human erythropoiesis by gamma interferon in vitro: role of monocytes and T lymphocytes. Journal of Clinical Investigation 75:1496-1503.
  3. Mamus SW, Burton J, Groat JD, Schulte DA, Lobelle N and Zanjani ED. (1986) Ibuprofen associated pure white cell aplasia. New England Journal of Medicine 314:624-625.
  4. Mamus SW, Oken MM and Zanjani ED. (1986) Cell-cell interactions erythropoiesis. Transfusion Medicine 227-244.
  5. Mamus SW, Oken MM and Zanjani ED. (1986) Suppression of normal human erythropoiesis by human recombinant DNA-produced alpha-2 interferon in vitro. Experimental Hematology 14:1015-1022.
  6. McGlave P, Mamus SW, Vilen B and DeWald G. (1987) Effect of recombinant gamma interferon on chronic myelogenous leukemia bone marrow progenitors. Experimental Hematology 15:331-335.
  7. Moulis H and Mamus SW. Isolated trochlear nerve palsy in a patient with Waldenstrom macroglobulinemia: Complete recovery with combination therapy. Neurology 36:1399.
  8. Giles FJ, Feldman EJ, Roboz GJ, Larson RA, Mamus SW, Cortes JE, Verstovsek S, Faderal S, Talpaz M, Beran M, Albitar M, O’Brien SM, and Kantarjian HM. (2003) Phase II study of Troxcitabine, a novel dioxolane nucleoside analog, in patients with untreated or Imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase. Leukemia Research 27:1091-1096.
  9. Sheikholeslami MR, Ma W, Uyeji J, Tornyos K, Cone L, Mamus S, Albitar M. (2007) Bi-clonal disease in patients with chronic lymphocytic leukemia as detected by analyzing IGHV mutation status. British Journal of Hematology 139:507-509.
  10. Cohn AL, Myers WJ, Mamus SW, Deur C, Nicol S, Hood K, Khan MM, Ilegbodu D, Asmar L. (2008) A phase II study of pemetrexed in patients with advanced hepatocellular carcinoma. Investigational New Drugs 26:381-386.

Abstracts

  1. Mamus, SW, Mladenovic J. and Kay NE. (1984) Cimetidine induced remission of mycosis fungoides. Clinical Research 32:418A.
  2. Mamus, SW and Zanjani, ED. (1984) Interfon-induced suppression of erythroid colony formation by normal human bone marrow cells in vitro. Experimental Hematology 12:366.
  3. Mamus, SW and Zanjani, ED. (1984) T lymphocytes activated with gamma interferon profoundly suppress human erythropoiesis in vitro. Clinical Research 32:789A.
  4. Mamus, SW and Zanjani, ED. (1984) Gamma interferon mediated suppression of human erythroid colonies in vitro is mediated primarily via immunocompetent cells. Fourth International Conference of Hemoglobin Switching. Bethesda, Maryland.
  5. Mamus, SW and Zanjani, ED. (1984) Gamma interferon induced suppression of erythroid colony formation by normal human bone marrow cells in vitro: Role of monocytes and T cells. Tenth Annual Frederick Stohlman Jr, MD Memorial Symposium. An International colloquium on stem cell physiology.
  6. Mamus, SW and Zanjani, ED. (1984) T lymphocytes activated with gamma interferon profoundly inhibit erythropoiesis in vitro. Blood, 64:131A.
  7. Mamus, SW, Confer D., Kay, NE and Zanjani, ED. (1985) T lymphocyte mediated suppression of erythropoiesis and granulopoiesis in chronic T cell lymphocytosis: Correlation of in vitro and in vivo findings. Clinical Research 33:34A.
  8. Mamus, SW, Oken, MM and Zanjani, ED. (1985) Suppression of normal human erythropoiesis by recombinant gamma but not alpha-2 interferon is dependent upon monocytes and T cells. Clinical Research 33:348A.
  9. Mamus, SW, Peterson, LC. And Belzer, M. (1985) Rapid reversal of leukopenia and thrombocytopenia in a homosexual man with Karposi sarcoma by splenectomy. Clinical Research 33:348A.
  10. Mamus, SW and Zanjani, ED. (1985) Suppression of normal human marrow CFU-GM by human gamma interferon in vitro: Modulation by immunocompetent cells and colony stimulating factor. Clinical Research 33:836A.
  11. Mamus, SW, Burton, J., Groat, J.D., Lobell, M. and Zanjani, ED. (1985) Mechanism of ibuprofen associated pure white cell aplasia, Clinical Research 33:836A.
  12. McGlave, P. and Mamus, SW. (1985) Suppression of erythropoiesis in patients with chronic myelogenous leukemia by recombinant alpha-2 interferon, Clinical Research 33:836A.
  13. Sheikholeslami M, Ma W, Uyeji J, Tornyos K, Cone L, Mamus S, Keating M, and Albitar M. (2005) Coexistence of Mutated and Unmutated IgVH Forms in Patients with Chronic Lymphocytic Leukemia, Blood 106: 4984.
  14. Cohn AL, Myers JW, Mamus S, Deur C, Nichol S, Hood K, Khan MM, IIegbodu D, Kochis J, and Asmar L. (2006) Single-agent pemetrexed in patients with advanced and metastatic hepatoma ASCO Gastrointestinal Symposium.

Research

1989-1990
Biotherapeutics Co-Principal Investigator Orlando Regional Healthcare System
1990-1991
Eastern Cooperative Oncology Group Co-Principal Investigator at Orlando Regional Healthcare System (ORHS)
1991-2004
Institutional Investigator for NSABP, GOG and RTOG trials
2000-2003
Director Institutional Review Board, MD Anderson Cancer Center Orlando
2004-2006
US Oncology co-investigator in phase I, II and III clinical trials sponsored by the pharmaceutical and biotechnology industries as well as studies sponsored by US Oncology
2005-2006
National Pharmaceutical and Therapeutics Committee, US Oncology
  • In 1989, Dr. Mamus was the first physician in the state of Florida to use Interleukin-2, TNF (tumor necrosis factor), and TIL (tumor infiltrating lymphocyte therapy) for the treatment of malignant melanoma and hypernephroma.
  • Dr. Mamus was the ORHS principle investigator on over 73 clinical trials.
  • In addition, he was co-investigator on over 20 trials with US Oncology.

Teaching Experience

1986-2005
Served as teaching attending at Orlando Regional Medical Center and, ultimately, at MD Anderson Cancer Center Orlando
Received “Excellence in Teaching” award from the American College of Physicians
2012-2014
Teaching attending, clinical assistant professor of medicine Florida State University
Teaching attending, associate clinical professor, Lake Erie College of Medicine

Speaking Experience

1984, 1985
American Federation for Clinical Research, Midwest Section
1986-2005
Four presentations per year to medical interns and residents at Orlando Regional Medical Center and MD Anderson Cancer Center, Orlando
2002
National Speakers Bureau, Astra-Zeneca Pharmaceuticals
1986-2011
Hospital Grand Rounds, on average, twice yearly

Other Experience

2010
3 hour Genentech-sponsored national call-in show regarding pancreatic cancer
2012
Channel 6 SNN News- Call-in show for questions about breast cancer
2013 Channel 7 ABC News- Medical segments related to Cancer
  1. Targeted therapy for cancer treatment
  2. PSA screening for prostate cancer
  3. Breast cancer risk related to use of blood pressure medication
  4. Tongue and head/neck Cancer
2014 Channel 7 ABC News- Medical segments related to Cancer
  1. New Surgeon General’s report
  2. Multiple Myeloma
  3. Tongue Cancer
  4. Laetrile, apricot pits and cancer
2015 Channel 7 ABC News- Medical segments related to Cancer
  1. Angelina Jolie/BRAC1/Prophylactic oopherectomy
  2. Right to Try Law

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