Steve Mamus

Steven W. Mamus, MD

Medical Director, Oncology/Hematology


Steve Mamus, MD is a nationally-renowned medical oncologist with more than two decades of expertise in the treatment of cancer and blood related disorders.

In November of 2006, Dr. Mamus founded the Cancer Center of Sarasota in order to bring personal, patient-centered care blended with university-based medical expertise to cancer patients in the Sarasota area. Dr. Mamus was instrumental in the development of MD Anderson Cancer Center — Orlando where he was chief of medical oncology and treated patients acutely affected by cancer for more than 10 years.

His oncology and hematology experience includes positions at Hematology/Oncology Associates of Central Florida from 1986 to 1991; Orlando Cancer Center from 1991 to 1994; and MD Anderson Cancer Center — Orlando from 1994 to 2004. Prior to developing the Cancer Center of Sarasota, he was a principal partner of Cancer Centers of Florida, a division of U.S. Oncology.

Dr. Mamus is recognized regionally and nationally with a long list of awards and accomplishments as an oncology/hematology physician, clinical research expert, and educator. He has been an investigator in more than 100 clinical trials involving a wide range of oncology/hematology modalities including biologic response modifiers, stem cell, bone marrow, and blood clotting abnormalities. He has published a number of articles and publications in peer-reviewed journals including The New England Journal of Medicine, Lancet, The Journal of Clinical Investigation and Leukemia Research.

Among his awards, Dr. Mamus was named a top physician by Best Doctors in America, Southeast Region for 14 consecutive years, and Attending Physician of the Year at Orlando Regional Medical Center. Dr. Mamus graduated with honors from Harvard and earned his M.D. from the State University of New York at Syracuse. He interned and completed his residency in Internal Medicine at Rush-Presbyterian
St. Luke’s Hospital in Chicago, and completed his fellowship in Hematology/Oncology at the University of Minnesota Hospital.

Dr. Mamus is board certified in Medical Oncology, Hematology, and Internal Medicine and is a member of the American Medical Association, Florida Medical Association, American Society of Hematology and the American Society of Clinical Oncology.
Dr. Mamus is of Ukrainian descent, was born in Canada, and lives in Sarasota with his wife Nancy, son and three daughters. Two of his daughters were adopted from the Ukraine and he has had a child with acute leukemia.


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    Education:

    July 1983 – June 1986 Fellow, Hematology/Oncology, University of Minnesota Hospital, Minneapolis, Minnesota
    July 1981 – June 1983 Resident, Internal Medicine, Rush-Presbyterian St. Luke’s Hospital Chicago, Illinois
    July 1980 – June 1981 Intern, Internal Medicine, Rush Presbyterian St. Luke’s Hospital Chicago, Illinois
    Aug 1976 – June 1980 MD- State University of New York at Syracuse
    Aug 1972 – June 1976 BA- Harvard College

    Licensure:

    Florida ME 48231

    Board Certification

    09/1983 American Board of Internal Medicine – Internal Medicine
    11/1986 American Board of Internal Medicine – Hematology
    11/1987 American Board of Internal Medicine – Medical Oncology

    Professional Experience:

    11/2006 – Present Medical Director- Cancer Center of Sarasota-Manatee, Sarasota and Bradenton, Florida
    2/2004 – 10/2006 Cancer Centers of Florida (US Oncology), Orlando, Florida
    7/1991 – 1/2004 M.D. Anderson Cancer Center – Orlando, Orlando, Florida
    7/1986- 7/1991 Hematology/Oncology Associates of Central Florida, Orlando, Florida

    Chronology of Employment & Appointments:

    1980-1983 Clinical Instructor, Rush Medical College, Chicago, Illinois
    1980-1981 Intern, Internal Medicine, Rush-Presbyterian St. Luke’s Hospital, Chicago, Illinois
    1981-1983 Resident, Internal Medicine, Rush-Presbyterian St. Luke’s Hospital, Chicago, Illinois
    1983-1986 Fellow, Hematology/Oncology, University of Minnesota Hospital
    1986-2006 Active Staff, Orlando Regional Medical Center, Orlando, Florida
    1986-2006 Active Staff, ORMC, Sand Lake Campus, Orlando, Florida
    1986-1991 Group Practice, Hematology/Oncology Associates of Central Florida, Orlando, Florida
    1986-1991 Courtesy Staff, Brookwood Community Hospital, Orlando, Florida
    1986-1992 Courtesy Staff, Florida Hospital, Orlando, Florida
    1991-1994 Orlando Cancer Center, Orlando, Florida
    1994-2004 M.D. Anderson Cancer Center Orlando, Florida
    2000-2003 Director, Institutional Review Board, MD Anderson, Orlando
    2002 National Speaker’s Bureau, Astra-Zeneca Pharmaceuticals
    2002 Advisory Board Southeast Region Astra-Zeneca
    2002 Executive Breast Cancer Advisory Council, Novartis Pharmaceuticals
    2002-2005 Speaker’s Bureau, Amgen
    2002-2004 Advisory Board Lilly Pharmaceuticals
    2002 Advisory Board Ortho Biotech
    2002-2003 Advisory Board Roche Pharmaceuticals
    1995-2005 Chief, Hematology-Medical Oncology, Orlando Regional
    2002-2003 Chief, Medical Oncology, MD Anderson-Orlando
    2002-2003 Section chief, Melanoma, MD Anderson-Orlando
    2002-2003 Section chief, Soft Tissue Sarcoma, MD Anderson-Orlando
    2002-2003 Section chief, Breast Carcinoma, MD Anderson-Orlando
    2004-2006 Active medical staff Florida Hospital System
    2004-2006 Active medical staff Health Central Hospital
    2005-2006 Active medical staff Osceola Regional Medical Center
    2005-2006 National Pharmaceutical and Therapeutics Committee, US Oncology
    2006-present Active Medical Staff- Sarasota Memorial Hospital, Manatee Memorial Hospital, Blake Hospital, Lakewood Ranch Hospital and Doctors’ Hospital
    2011-present Clinical Assistant Professor, Florida State University School of Medicine
    2012-present Lab Director Max Health, High Complexity Laboratory
    2013 Steering Committee, Hospitalist Service, Sarasota Memorial Hospital
    2014-present Clinical Associate Professor, Lake Erie College of Osteopathic Medicine (LECOM)
    2014-present Chief of Hematology, Blake trauma unit

    Hospitals:

    Active Medical Staff Memberships

    Sarasota Memorial Hospital
    Doctors Hospital of Sarasota
    Manatee Memorial Healthcare System
    Blake Medical Center
    Lakewood Ranch Medical Center

    Inactive Medical Staff Memberships

    Florida Hospital Healthcare System
    Florida Hospital South
    Florida Hospital East
    Florida Hospital North
    Florida Hospital Kissimmee
    South Lake Hospital
    Orlando Regional Medical Center
    Health Central Hospital

    Societies:

    1982-Present American Medical Association
    1982-1983 American College of Emergency Physicians
    1983-1986 American College of Physicians
    1984-1986 American Federation for Clinical Research
    1986-Present Florida Medical Association
    1986-2006 Orange County Medical Society
    1986-Present American Society of Hematology
    1988-1989 Board of Trustees, Leukemia Society of America, Orlando Chapter
    1989-Present American Society of Clinical Oncology
    2007-Present Sarasota County Medical Society
    2009-Present Manatee County Medical Society
    2013-Present American Association of Cancer Research

    Awards:

    1976 BA, cum laude, Harvard College
    1984 Third Prize, Officer-Fellow Abstract Award, American Federation for
    Clinical Research, Midwestern Section
    1985 First Prize, Midwest Trainee Award, American Federation for Clinical Research, Midwestern Section
    1986 Research grant for study of Interferon Effects on Normal Hematopoiesis
    National Institutes of Health, Heart and Lung Institute (unrestricted individual grant for $450,000.00-declined in favor of private practice).
    1987 Attending Physician of the Year, Orlando Regional Medical Center, Department of Internal Medicine
    1996 The Best Doctors in America, Southeast Region
    1997 The Best Doctors in America, Southeast Region
    1998 The Best Doctors in America, Southeast Region
    1999 The Best Doctors in America, Southeast Region
    2000 The Best Doctors in America, Southeast Region
    2001 The Best Doctors in America, Southeast Region
    2001 American College of Physicians Excellence in Teaching Award
    2002 The Best Doctors in America, Southeast Region
    2003 The Best Doctors in America, Southeast Region
    2004 The Best Doctors in America, Southeast Region
    2005 The Best Doctors in America, Southeast Region
    2006 The Best Doctors in America, Southeast Region
    2007 The Best Doctors in America, Southeast Region
    2008 The Best Doctors in America, Southeast Region
    2009 The Best Doctors in America, Southeast Region
    2010 The Best Doctors in America, Southeast Region
    2011 The Best Doctors in America, Southeast Region
    2011 Best Doctors, Sarasota Magazine, U.S. News and World Report
    2012 People’s Physician Choice Award
    2012 The Best Doctors in America, Southeast Region
    2012 Best Doctors, Sarasota Magazine, U.S. News and World Report
    2013 Best Doctors, Sarasota Magazine, U.S. News and World Report
    2013 The Best Doctors in America, Southeast Region
    2013 People’s Physician Choice Award
    2014 Best Doctors, Sarasota Magazine, U.S. News and World Report
    2014 The Best Doctors in America, Southeast Region
    2015 Chosen by the International Association of Oncologists as a Top Oncologist in Sarasota, FL and listed in the publication The Leading Physicians of the World
    2015 Best Doctors, Sarasota Magazine, U.S. News and World Report
    2015 The Best Doctors in America, Southeast Region

    PUBLICATIONS:

    1. Mamus SW, Mladenovic J, Hordinsky MK, Dahl M and Kay NE. (1984) Cimetidine induced remission of mycosis fungoides. Lancet, II: 409.

    2. Mamus SW, Beck-Schroeder SL and Zanjani ED. (1985) Suppression of normal human erythropoiesis by gamma interferon in vitro: role of monocytes and T lymphocytes. Journal of Clinical Investigation 75:1496-1503.

    3. Mamus SW, Burton J, Groat JD, Schulte DA, Lobelle N and Zanjani ED. (1986) Ibuprofen associated pure white cell aplasia. New England Journal of Medicine 314:624-625.

    4. Mamus SW, Oken MM and Zanjani ED. (1986) Cell-cell interactions erythropoiesis. Transfusion Medicine 227-244.

    5. Mamus SW, Oken MM and Zanjani ED. (1986) Suppression of normal human erythropoiesis by human recombinant DNA-produced alpha-2 interferon in vitro. Experimental Hematology 14:1015-1022.

    6. McGlave P, Mamus SW, Vilen B and DeWald G. (1987) Effect of recombinant gamma interferon on chronic myelogenous leukemia bone marrow progenitors. Experimental Hematology 15:331-335.

    7. Moulis H and Mamus SW. Isolated trochlear nerve palsy in a patient with Waldenstrom macroglobulinemia: Complete recovery with combination therapy. Neurology 36:1399.

    8. Giles FJ, Feldman EJ, Roboz GJ, Larson RA, Mamus SW, Cortes JE, Verstovsek S, Faderal S,
    Talpaz M, Beran M, Albitar M, O’Brien SM, and Kantarjian HM. (2003) Phase II study of
    Troxcitabine, a novel dioxolane nucleoside analog, in patients with untreated or Imatinib
    mesylate-resistant chronic myelogenous leukemia in blastic phase. Leukemia Research
    27:1091-1096.

    9. Sheikholeslami MR, Ma W, Uyeji J, Tornyos K, Cone L, Mamus S, Albitar M. (2007) Bi-clonal
    disease in patients with chronic lymphocytic leukemia as detected by analyzing IGHV mutation
    status. British Journal of Hematology 139:507-509.

    10. Cohn AL, Myers WJ, Mamus SW, Deur C, Nicol S, Hood K, Khan MM, Ilegbodu D, Asmar L.
    (2008) A phase II study of pemetrexed in patients with advanced hepatocellular carcinoma. Investigational New Drugs 26:381-386.

    ABSTRACTS:

    1. Mamus, SW, Mladenovic J. and Kay NE. (1984) Cimetidine induced remission of mycosis fungoides. Clinical Research 32:418A.

    2. Mamus, SW and Zanjani, ED. (1984) Interfon-induced suppression of erythroid colony formation by normal human bone marrow cells in vitro. Experimental Hematology 12:366.

    3. Mamus, SW and Zanjani, ED. (1984) T lymphocytes activated with gamma interferon profoundly suppress human erythropoiesis in vitro. Clinical Research 32:789A.

    4. Mamus, SW and Zanjani, ED. (1984) Gamma interferon mediated suppression of human erythroid colonies in vitro is mediated primarily via immunocompetent cells. Fourth International Conference of Hemoglobin Switching. Bethesda, Maryland.

    5. Mamus, SW and Zanjani, ED. (1984) Gamma interferon induced suppression of erythroid colony formation by normal human bone marrow cells in vitro: Role of monocytes and T cells. Tenth Annual Frederick Stohlman Jr, MD Memorial Symposium. An International colloquium on stem cell physiology.

    6. Mamus, SW and Zanjani, ED. (1984) T lymphocytes activated with gamma interferon profoundly inhibit erythropoiesis in vitro. Blood, 64:131A.

    7. Mamus, SW, Confer D., Kay, NE and Zanjani, ED. (1985) T lymphocyte mediated suppression of erythropoiesis and granulopoiesis in chronic T cell lymphocytosis: Correlation of in vitro and in vivo findings. Clinical Research 33:34A.

    8. Mamus, SW, Oken, MM and Zanjani, ED. (1985) Suppression of normal human erythropoiesis by recombinant gamma but not alpha-2 interferon is dependent upon monocytes and T cells. Clinical Research 33:348A.

    9. Mamus, SW, Peterson, LC. And Belzer, M. (1985) Rapid reversal of leukopenia and thrombocytopenia in a homosexual man with Karposi sarcoma by splenectomy. Clinical Research 33:348A.

    10. Mamus, SW and Zanjani, ED. (1985) Suppression of normal human marrow CFU-GM by human gamma interferon in vitro: Modulation by immunocompetent cells and colony stimulating factor. Clinical Research 33:836A.

    11. Mamus, SW, Burton, J., Groat, J.D., Lobell, M. and Zanjani, ED. (1985) Mechanism of ibuprofen associated pure white cell aplasia, Clinical Research 33:836A.

    12. McGlave, P. and Mamus, SW. (1985) Suppression of erythropoiesis in patients with chronic myelogenous leukemia by recombinant alpha-2 interferon, Clinical Research 33:836A.

    13. Sheikholeslami M, Ma W, Uyeji J, Tornyos K, Cone L, Mamus S, Keating M, and Albitar M.
    (2005) Coexistence of Mutated and Unmutated IgVH Forms in Patients with Chronic
    Lymphocytic Leukemia, Blood 106: 4984.

    14. Cohn AL, Myers JW, Mamus S, Deur C, Nichol S, Hood K, Khan MM, IIegbodu D, Kochis J, and
    Asmar L. (2006) Single-agent pemetrexed in patients with advanced and metastatic hepatoma
    ASCO Gastrointestinal Symposium

    RESEARCH

    1989-1990 Biotherapeutics Co-Principal Investigator Orlando Regional Healthcare System
    1990-1991 Eastern Cooperative Oncology Group Co-Principal Investigator at Orlando Regional Healthcare System (ORHS)
    1991-2004 Institutional Investigator for NSABP, GOG and RTOG trials.
    2000-2003 Director Institutional Review Board, MD Anderson Cancer Center Orlando
    2004-2006 US Oncology co-investigator in phase I, II and III clinical trials sponsored by the pharmaceutical and biotechnology industries as well as studies sponsored by US Oncology.

    2005-2006 National Pharmaceutical and Therapeutics Committee, US Oncology

    • In 1989, Dr. Mamus was the first physician in the state of Florida to use Interleukin-2, TNF (tumor necrosis factor), and TIL (tumor infiltrating lymphocyte therapy) for the treatment of malignant melanoma and hypernephroma.
    • Dr. Mamus was the ORHS principle investigator on over 73 clinical trials (see attached).
    • In addition, he was co-investigator on over 20 trials with US Oncology.

    TEACHING EXPERIENCE:

    1986-2005 Served as teaching attending at Orlando Regional Medical Center and, ultimately, at MD Anderson Cancer Center Orlando
    Received “Excellence in Teaching” award from the American College of Physicians
    2012-2014 Teaching attending, clinical assistant professor of medicine Florida State University
    Teaching attending, associate clinical professor, Lake Erie College of Medicine

    SPEAKING EXPERIENCE

    1984, 1985 American Federation for Clinical Research, Midwest Section
    1986-2005 Four presentations per year to medical interns and residents at Orlando Regional Medical Center and MD Anderson Cancer Center, Orlando
    2002 National Speakers Bureau, Astra-Zeneca Pharmaceuticals
    1986-2011 Hospital Grand Rounds, on average, twice yearly

    OTHER EXPERIENCE

    2010 3 hour Genentech-sponsored national call-in show regarding pancreatic cancer
    2012 Channel 6 SNN News- Call-in show for questions about breast cancer

    2013 Channel 7 ABC News- Medical segments related to Cancer

    1. Targeted therapy for cancer treatment
    2. PSA screening for prostate cancer
    3. Breast cancer risk related to use of blood pressure medication
    4. Tongue and head/neck Cancer

    2014 Channel 7 ABC News- Medical segments related to Cancer

    1. New Surgeon General’s report
    2. Multiple Myeloma
    3. Tongue Cancer
    4. Laetrile, apricot pits and cancer

    2015 Channel 7 ABC News- Medical segments related to Cancer

    1. Angelina Jolie/BRAC1/Prophylactic oopherectomy
    2. Right to Try Law

    Address

    Cancer Center of Sarasota-Manatee
    3830 Bee Ridge Rd #301
    Sarasota, FL 34233
    USA

    tel: (941) 923-1872

    4351 Cortez Road West, Ste 100
    Bradenton, FL 34210
    USA

    tel: (941) 755-0606
    email: info@cancersarasota.com

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